OcuTox performs drug interaction studies with ocular cell lines
Primary RPE cell culture from human
or primary cells particularly with retinal pigment epithelial cells (RPE) and endothelial cells. Quantitative data from cell culture experiments are mostly evaluated by image stream analysis
Study endpoints are
Cell viability
Phagocytosis with Image Stream or EM
RPE hyperthrophy
Drug pigment interaction assessment
Melanin binding
Lysosomal pH
Lysosomal enzyme activity
Protein synthesis
Cell polarity
Protein quantification and detection by immuno cytochemistry
Phospholipidosis
Cellular junctions
Fenestrations
Extracellular matrices
others