- CORNEAL neovascularization
- RETINAL neovascularization animal model of oxygen-induced retinopathy (OIR)
- CHOROIDAL neovascularization experimental argon laser-induced choroidal neovascularization (CNV model), AAV induced transfection and overexpression of VEGF after subretinal injection
- Choroidal neovascularisation induced by VEGF over expression in a rat
Degeneration of the choricapillaris (sodium iodate)
Applications
- Proof of concept for angiogenesis
- Corneal angiogenesis
- Retinal angiogenesis
- Retinopathy of prematurity
- diabetic retinopathy
- Choroidal angiogenesis wet age-related macular degeneration (AMD)
- Dry AMD
Choroidal neovascularisation induced by VEGF over expression in a rabbit
D) FA angiography E) ICG angiography D) migration of endothelial cells (C) through Bruch´s membrane (arrowhead)
Choroidal neovascularisation induced by VEGF over expression in a rat
left) FA angiography middle) ICG angiography right) merged image
Evaluations
- Length of new vessels and network density
- Angiography (HRA)
- SLO angiography from the the fovea of a monkey
- Histology (number of new vessels …)
- Retina examination (fundus, HRT)
- Corneal examination (HRT)
- Visualization and quantification of size of the lesion in the CNV model (flatmount evaluation)
- Fenestration (EM)
- A choriocapillaris from a monkey contains many fenestrations (arrow) towards Bruch´s membrane
- Bruch´s membrane
- Immuno-cytochemistry