Early testing

Before performing proof of concept or efficacy studies, OcuTox suggests a short term evaluation of the ocular tolerance of the compound or formulation in a small number of animals. These early studies are used to identify any observable signs of toxicity, and provide a base for decisions whether the development of the substances should be continued with more detailed studies.

Eye Irritaion

The tests can be performed ex vivo according to the OECD guidelines 438,437 or 492

https://www.oecd-ilibrary.org/environment/test-no-438-isolated-chicken-eye-test-method-for-identifying-ocular-corrosives-and-severe-irritants_9789264076310-en

https://www.oecd-ilibrary.org/environment/test-no-492-reconstructed-human-cornea-like-epithelium-rhce-test-method-for-identifying-chemicals-not-requiring-classification-and-labelling-for-eye-irritation-or-serious-eye-damage_9789264242548-en

https://www.oecd-ilibrary.org/environment/test-no-437-bovine-corneal-opacity-and-permeability-test-method-for-identifying-i-chemicals-inducing-serious-eye-damage-and-ii-chemicals-not-requiring-classification-for-eye-irritation-or-serious-eye-damage_9789264203846-en